University Health Network (UHN)/Toronto Western Hospital (TWH)
Dr. Maria Cino is an Associate Professor of Medicine at the University of Toronto and is a clinical Gastroenterologist at the Toronto Western Hospital – University Health Network (TWH-UHN). Dr. Cino holds an Honours BSc in Biochemistry from McMaster University, and a Master of Science degree in Biochemistry from the University of Western Ontario. Dr. Cino is a graduate of McMaster Medical School. Training in Internal Medicine and Gastroenterology was undertaken at the University of Toronto. Dr. Cino underwent additional postgraduate clinical training as a clinical fellow / associate staff in inflammatory bowel disease at the Mount Sinai Hospital in Toronto prior to joining TWH-UHN in 2001. Major clinical interests include inflammatory bowel disease and celiac disease with a focus on metabolic consequences of these illnesses. Dr. Cino has a major commitment to teaching at the University of Toronto at the undergraduate and postgraduate levels. Dr. Cino has held the position of Program Director for the Division of Gastroenterology Residency Training Program since 2007. Dr. Cino sits on the Canadian Association of Gastroenterology (CAG) education committee, and is the co-chair of the CAG Basic Science Rounds. Dr. Cino is also a member of the Gastroenterology Board of Examiners for the Royal College of Physicians and Surgeons of Canada.
Dr. Herbert Gaisano received his MD (1981) from the University of Phillipines, and his Gastroenterology training at the Mayo Graduate School of Medicine, Rochester, Minnesota. He is currently a Professor of Medicine at the University of Toronto. Dr. Gaisano oversees a vigorous research program. His laboratory is focused on the molecular mechanisms that regulate exocytosis, using two models- the neuroendocrine insulin-secreting pancreatic islet beta cell and the epithelial pancreatic acinar cell - which secrete digestive enzymes. His lab is mainly interested in SNARE proteins, originally described to regulate neurotransmitter release, but subsequently found to be highly conserved in neuroendocrine and non-excitable secretory cells to regulate secretion. Dr. Gaisano and colleagues were the first to identify the combinations of SNARE proteins which mediate the distinct exocytic events in the acinar cell (apical and basolateral exocytosis, homotypic granule fusion) and the pancreatic islet beta cell. Insights from Dr. Gaisano's research are of direct impact on normal secretory biology and pathobiology, particularly in understanding the dysregulated insulin secretion in diabetes and pathologic membrane fusion in pancreatitis and also membrane ion channel biology of cardiac and gastrointestinal muscles in health and in disease.
Received BM Degree in Medicine from University of Southampton, United Kingdom (1989). Received FRACP Degree in Internal Medicine and Gastroenterology/Hepatology from Royal Australasian College of Physicians, Australia (2001). Received DM Degree in Hepatitis C and Fibrosis from University of Southampton, United Kingdom (2007).
I have a long-standing interest in clinical and translational research relating to host metabolic risk factors and mechanisms of fibrosis in chronic hepatitis C infection, development of non-invasive markers for liver fibrosis, along with the incorporation of functional genomic tools in the development of blood biomarkers of disease progression. My clinical research interests include the development of early phase clinical therapeutic trials for anti-fibrotic compounds, and I have been the coordinating center or site-based principal investigator at our institution for several phase I-III clinical therapeutic and post-approval phase IV registry studies for viral hepatitis and chronic liver disease.