Journal Headlines

Gut

Unravelling the multiple roles of apolipoprotein E in the hepatitis C virus life cycle

Worldwide, about 3% of the population is infected with HCV, and chronic infection is associated with a risk of serious…

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Helicobacter pylori-induced cell death is counteracted by NF-{kappa}B-mediated transcription of DARPP-32

Objective

DARPP-32 is a frequently amplified and overexpressed gene that promotes several oncogenic functions in gastric cancer. Herein, we investigated…

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NF-{kappa}B mediated transcription of DARPP-32 prevents Helicobacter pylori-induced cell death

Gastric cancer remains one of the leading neoplasms and currently ranks third in cancer mortality worldwide.1 Helicobacter pylori

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Shall we blame CD4 T cells for everything?

Persistent inflammatory conditions in the liver promote chronic liver damage and liver fibrosis ultimately leading to hepatocellular carcinoma (HCC). Multiple…

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Updated guideline on the management of common bile duct stones (CBDS)

Common bile duct stones (CBDS) are estimated to be present in 10–20% of individuals with symptomatic gallstones. They can result…

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Hepatology

Polo‐like‐kinase 1 is a proviral host‐factor for hepatitis B virus replication

Chronic Hepatitis B Virus (HBV) infection is a major risk factor for hepatocellular carcinoma (HCC) and current treatments for CHB…

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Protein disulfide isomerase inhibition synergistically enhances the efficacy of sorafenib for hepatocellular carcinoma

Sorafenib is the only approved targeted drug for hepatocellular carcinoma (HCC), but its effect on patients' survival gain is limited…

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SIRT1/HSF1/HSPs Pathway is Essential for Exenatide‐alleviated Lipid‐induced Hepatic Endoplasmic Reticulum Stress

Recent studies have indicated lipid‐induced endoplasmic reticulum (ER) stress to be a major contributor to the progression of hepatic steatosis.…

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Reply (to LTE 17‐0412)

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Reply Letter

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